Considerations for Experimental Animal Models of Concussion, Traumatic Brain Injury, and Chronic Traumatic Encephalopathy-These Matters Matter.

摘要: Animal models of concussion, traumatic brain injury (TBI), and chronic encephalopathy (CTE) are widely available routinely deployed in laboratories around the world. Effective animal modeling requires careful consideration four basic principles. First, model use must be guided by clarity definitions regarding human disease or condition being modeled. Concussion, TBI, CTE represent distinct clinical entities that require clear differentiation: concussion is a neurological syndrome, TBI event, disease. While these conditions all associated with head injury, pathophysiology, course, medical management each distinct. Investigators who take into account distinctions to avoid misinterpretation results category mistakes. Second, selection grounded purpose respect experimental questions frame reference investigation. Distinguishing context (“inputs”) from consequences (“outputs”) may helpful during selection, design execution, interpretation results. Vigilance required rout out, rigorously control for, artifacts potential interfere primary endpoints. The widespread anesthetics many illustrates ways can confound preclinical Third, concordance between key features modeled confirm biofidelity. Fourth, observed animals confirmed subjects for validation. Adherence principles serves as bulwark against flawed results, study replication failure, confusion field. Implementing will advance science discovery accelerate translation benefit people affected CTE.