Development of a Sensing Array for Human Breath Analysis Based on SWCNT Layers Functionalized with Semiconductor Organic Molecules.

摘要: A sensor array based on heterojunctions between semiconducting organic layers and single walled carbon nanotube (SWCNT) films is produced to explore applications in breathomics, the molecular analysis of exhaled breath. The exposed gas/volatiles relevant specific diseases (ammonia, ethanol, acetone, 2-propanol, sodium hypochlorite, benzene, hydrogen sulfide, nitrogen dioxide). Then, evaluate its capability operate with real biological samples human breath from healthy subjects. Finally, provide a proof concept diagnostic potential, collected subjects chronic obstructive pulmonary disease (COPD), an airway inflammatory not yet investigated CNT-based arrays, breathprints are compared those obtained Principal component shows that able detect various target clear fingerprint 2D subspace, suitable for profiling breath, distinguish COPD their breathprints. This classification ability further improved by selecting most responsive sensors dioxide, potential biomarker COPD.