Medicinal gold compounds form tight adducts with the copper chaperone Atox-1: biological and pharmacological implications.
作者： Chiara Gabbiani , Federica Scaletti , Lara Massai , Elena Michelucci , Maria A. Cinellu
DOI: 10.1039/C2CC36610J
关键词:
摘要: Based on ESI-MS measurements, we show here that some representative cytotoxic gold(III) compounds produce stable adducts upon reaction with the copper chaperone Atox-1; notably, such contain gold in oxidation state +1. These findings are of interest to understand intracellular metabolism medicinal species and develop new potent inhibitors trafficking system.
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Roohangiz Safaei, Goli Samimi, Myriam Rochdi, Alison Holzer, Akira Kondo, Misako Mishima, Stephen B Howell, Yien-Ming Kuo, Kuniyuki Katano, Acquisition of resistance to cisplatin is accompanied by changes in the cellular pharmacology of copper. Cancer Research. ,vol. 62, pp. 6559- 6565 ,(2002)
Maria E Palm, Christoph F Weise, Christina Lundin, Gunnar Wingsle, Yvonne Nygren, Erik Björn, Peter Naredi, Magnus Wolf-Watz, Pernilla Wittung-Stafshede, Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro Proceedings of the National Academy of Sciences of the United States of America. ,vol. 108, pp. 6951- 6956 ,(2011) , 10.1073/PNAS.1012899108
Maria E. Palm-Espling, Pernilla Wittung-Stafshede, Reaction of platinum anticancer drugs and drug derivatives with a copper transporting protein, Atox1 Biochemical Pharmacology. ,vol. 83, pp. 874- 881 ,(2012) , 10.1016/J.BCP.2012.01.018
Roohangiz Safaei, Stephen B. Howell, Copper transporters regulate the cellular pharmacology and sensitivity to Pt drugs Critical Reviews in Oncology Hematology. ,vol. 53, pp. 13- 23 ,(2005) , 10.1016/J.CRITREVONC.2004.09.007
Massimiliano Stola, Francesco Musiani, Stefano Mangani, Paola Turano, Niyaz Safarov, Barbara Zambelli, Stefano Ciurli, The nickel site of Bacillus pasteurii UreE, a urease metallo-chaperone, as revealed by metal-binding studies and X-ray absorption spectroscopy. Biochemistry. ,vol. 45, pp. 6495- 6509 ,(2006) , 10.1021/BI0601003
Leonard Kaps, Bernhard Biersack, Helge Müller-Bunz, Katharina Mahal, Julienne Münzner, Matthias Tacke, Thomas Mueller, Rainer Schobert, Gold(I)-NHC complexes of antitumoral diarylimidazoles: structures, cellular uptake routes and anticancer activities. Journal of Inorganic Biochemistry. ,vol. 106, pp. 52- 58 ,(2012) , 10.1016/J.JINORGBIO.2011.08.026
Lucia Banci, Ivano Bertini, Francesca Cantini, Simone Ciofi-Baffoni, Cellular copper distribution: a mechanistic systems biology approach Cellular and Molecular Life Sciences. ,vol. 67, pp. 2563- 2589 ,(2010) , 10.1007/S00018-010-0330-X
Giordana Marcon, Stefania Carotti, Marcella Coronnello, Luigi Messori, Enrico Mini, Pierluigi Orioli, Teresita Mazzei, Maria Agostina Cinellu, Giovanni Minghetti, Gold(III) Complexes with Bipyridyl Ligands: Solution Chemistry, Cytotoxicity, and DNA Binding Properties Journal of Medicinal Chemistry. ,vol. 45, pp. 1672- 1677 ,(2002) , 10.1021/JM010997W
Angela Casini, Maria Agostina Cinellu, Giovanni Minghetti, Chiara Gabbiani, Marcella Coronnello, Enrico Mini, Luigi Messori, None, Structural and solution chemistry, antiproliferative effects, and DNA and protein binding properties of a series of dinuclear gold(III) compounds with bipyridyl ligands. Journal of Medicinal Chemistry. ,vol. 49, pp. 5524- 5531 ,(2006) , 10.1021/JM060436A
Amie K. Boal, Amy C. Rosenzweig, Structural biology of copper trafficking. Chemical Reviews. ,vol. 109, pp. 4760- 4779 ,(2009) , 10.1021/CR900104Z