Response to: “Misunderstanding the PROPPR trial”

Terence O’Keeffe, Sandro Rizoli, Bryce R. H. Robinson, Thomas M. Scalea, Martin A. Schreiber, Deborah M. Stein, Jordan A. Weinberg, Jeannie L. Callum, John R. Hess, Nena Matijevic, Christopher N. Miller, Jean-Francois Pittet, David B. Hoyt, Gail D. Pearson, Brian Leroux, Gerald van Belle, John B. Holcomb, Barbara C. Tilley, Sarah Baraniuk, Erin E. Fox, Charles E. Wade, Jeanette M. Podbielski, Deborah J. del Junco, Karen J. Brasel, Eileen M. Bulger, Rachael A. Callcut, Mitchell Jay Cohen, Bryan A. Cotton, Timothy C. Fabian, Kenji Inaba, Jeffrey D. Kerby, Peter Muskat, Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients With Severe Trauma JAMA. ,vol. 313, pp. 471- 482 ,(2015) , 10.1001/JAMA.2015.12

Ronald Chang, Jessica C. Cardenas, Charles E. Wade, John B. Holcomb, Advances in the understanding of trauma-induced coagulopathy Blood. ,vol. 128, pp. 1043- 1049 ,(2016) , 10.1182/BLOOD-2016-01-636423

Philip C. Spinella, Andrew P. Cap, Whole blood: back to the future. Current Opinion in Hematology. ,vol. 23, pp. 536- 542 ,(2016) , 10.1097/MOH.0000000000000284

Ronald Chang, Lindley E. Folkerson, Duncan Sloan, Jeffrey S. Tomasek, Ryan S. Kitagawa, H. Alex Choi, Charles E. Wade, John B. Holcomb, Early plasma transfusion is associated with improved survival after isolated traumatic brain injury in patients with multifocal intracranial hemorrhage Surgery. ,vol. 161, pp. 538- 545 ,(2017) , 10.1016/J.SURG.2016.08.023

Jeremy W. Cannon, Mansoor A. Khan, Ali S. Raja, Mitchell J. Cohen, John J. Como, Bryan A. Cotton, Joseph J. Dubose, Erin E. Fox, Kenji Inaba, Carlos J. Rodriguez, John B. Holcomb, Juan C. Duchesne, Damage control resuscitation in patients with severe traumatic hemorrhage: A practice management guideline from the Eastern Association for the Surgery of Trauma. Journal of Trauma-injury Infection and Critical Care. ,vol. 82, pp. 605- 617 ,(2017) , 10.1097/TA.0000000000001333

Erin E Fox, John B Holcomb, Charles E Wade, Eileen M Bulger, Barbara C Tilley, PROPPR Study Group, Earlier Endpoints are Required for Hemorrhagic Shock Trials Among Severely Injured Patients Shock. ,vol. 47, pp. 567- 573 ,(2017) , 10.1097/SHK.0000000000000788

Meghan Delaney, Paul C. Stark, Minhyung Suh, Darrell J. Triulzi, John R. Hess, Marie E. Steiner, Christopher P. Stowell, Steven R. Sloan, Massive Transfusion in Cardiac Surgery: The Impact of Blood Component Ratios on Clinical Outcomes and Survival. Anesthesia & Analgesia. ,vol. 124, pp. 1777- 1782 ,(2017) , 10.1213/ANE.0000000000001926

Patrick E. Georgoff, Vahagn C. Nikolian, Ihab Halaweish, Kiril Chtraklin, Peter J. Bruhn, Hassan Eidy, Monica Rasmussen, Yongqing Li, Ashok Srinivasan, Hasan B. Alam, Resuscitation with Lyophilized Plasma Is Safe and Improves Neurological Recovery in a Long-Term Survival Model of Swine Subjected to Traumatic Brain Injury, Hemorrhagic Shock, and Polytrauma Journal of Neurotrauma. ,vol. 34, pp. 2167- 2175 ,(2017) , 10.1089/NEU.2016.4859