Glutamate decarboxylase-, insulin-, and islet cell-antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children.

作者： W A Hagopian , C B Sanjeevi , I Kockum , M Landin-Olsson , A E Karlsen

关键词:

摘要: Most autoimmune diabetes occurs in those without a diabetic relative, but few cases are identifiable prospectively. To model general population prediction, 491 consecutive newly children from all of Sweden were tested for autoantibodies to glutamate decarboxylase (GAD65ab), insulin (IAA), and islet cells (ICA), HLA-DQ genotypes by PCR; 415 matched control parallel. GAD65ab sensitivity/specificity was 70/96%, versus 84/96% ICA, 56/97% IAA, 93/93% (any positive), 39/99.7% (all 41/99.7% (GAD65ab plus IAA). The latter's 25% predictive value not improved requiring concomitant high-risk HLA genotypes. associated with DQA1*0501/B1*0201 (DQ2; P = 0.007) DQA1*0301/B1*0302 (DQ8), IAA (DQ8; 0.03) (DQ2). more prevalent females than males (79 vs. 63%; < 0.0001) did vary onset age nor season. Combining the three antibody assays yielded sufficient sensitivity screening. GADab relatively sensitive/specific diabetes, even marker combinations values insufficient early immunointervention low-prevalence population.

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Glutamate decarboxylase-, insulin-, and islet cell-antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children.

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Glutamate decarboxylase-, insulin-, and islet cell-antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children.

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