5 - Role of Immunohistochemical Expression of Ki-67 in Adenocarcinoma of Large Intestine
作者： Dziegiel Piotr , Zabel Maciej
DOI: 10.1016/S1874-5784(05)80067-4
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摘要: This chapter discusses the results of multiannual studies on large intestine carcinoma, describing role Ki-67 antigen expression, in correlation with selected clinicopathologic parameters. The expression metallothionein (MT), protein affecting proliferation, and differentiation cells is also discussed chapter. intensities MT are compared intensity apoptosis adenocarcinoma. Tumor growth progression represent result its proliferative activity capacity eliminating cancer by apoptosis, necrosis, or both. Intensified proliferation neoplastic leads to augmented volume mass tumor that may induce, within processes, leading necrosis. exponents indirectly provide markers cell proliferation. In large-intestine adenocarcinomas parallel antigen, apoptotic process (terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling [TUNEL]), immunohistochemical cas-3 described application used as an index sensitivity chemotherapy. Tumors a high exhibiting intense found be more sensitive chemotherapy radiotherapy.
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