Focal Adhesion Kinase with the Interacting Proteins and Signaling in Cancer

摘要: Human cancer is characterized by a process of tumor cell motility, invasion, and metastasis. One the critical tyrosine kinases that linked to these processes invasion survival Focal Adhesion Kinase (FAK). Our laboratory was first isolate FAK from human tumors, in our initial report, we demonstrated mRNA upregulated invasive metastatic breast colon samples. We identified several binding partners cells, such as RIP, VEGFR-3, p53, IGFR proteins. Recently, have cloned promoter found contains p53 sites, inhibits transcription regulates its expression In addition, N-MYCN binds induces neuroblastoma cells. Thus, will review structure discuss novel proteins pathways interacting with role FAK-mediated signaling tumorigenesis (especially breast, colon, pancreatic, cancers). this be focused on signal transduction FAK-targeted therapy, linking extracellular matrix nucleus