Biologic rhythms and Parkinson's disease: a chronopharmacologic approach to considering fluctuations in function.

摘要: The existence of circadian rhythms and their implication in many pathologic processes have been underlined several diseases but not evaluated Parkinson's disease. aim this paper is to review diurnal variations clinical, biologic, or experimental factors described with Clinical data often report daily fluctuations motor activity pattern, the effect stage disease respective roles drugs are difficult evaluate. Sleep disturbances patients also reveal alterations rhythms. Autonomic dysfunction, disease, reveals numerous regulations including loss rhythm blood pressure, increased pressure variability, postprandial hypotension. Many biologic indices such as cortisol, catecholamines, melatonin altered. Circadian dopaminergic systems well possible kinetics drug treatments likely involved variations. Few clinical studies devoted patterns response. As for other where concerned therapy may be influenced by further understanding influence.