HIV protease inhibitor ritonavir induces lipoatrophy in male mice.
作者： Eric S. Goetzman , Liqun Tian , Tim R. Nagy , Barbara A. Gower , Trenton R. Schoeb
DOI: 10.1089/088922203771881248
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摘要: We investigated the effects of HIV protease inhibitor ritonavir on body composition, serum lipids, and gene expression in C57BL/6 mice. Dual-energy X-ray absorptiometry measurements ritonavir-treated male mice revealed whole-body lipoatrophy. In female fat reduction was restricted to gonadal depot. A histopathological analysis showed no visible abnormalities liver or adipose tissue from mice, although adipocytes were significantly smaller diameter. Serum triglyceride levels increased Ritonavir coadministered with peroxisome proliferator-activated receptor α (PPARα) agonist gemfibrozil PPARγ rosiglitazone for 8 weeks. Neither drug alleviated hypertriglyceridemia lipoatrophy Rather, exacerbated reduced basal two PPARα target genes liver, as well phosphoenolpyruvate carboxykinase (PEPCK) ...
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