18 – HIV VACCINES: MILESTONES AND NEW INSIGHTS

摘要: This chapter focuses on the reason behind growing conviction that an HIV vaccine is possible, with many obstacles and difficulties still unresolved. Despite extensive research have gone into pathogenesis etiology of human immunodeficiency virus (HIV), a to prevent infection elusive for more than 15 years after first milestone in HIV/AIDS was achieved—that is, identification as causative agent acquired syndrome (AIDS). Various strategies stimulate protective immune response against are being explored through basic research, evaluation animal models, clinical trials. There various inherent uncertainties responses required protection or disease, designs needed induce such responses. Conducting small trials early product development process affords opportunity rapidly return laboratory incorporate improvements refine promising candidates less optimal