Risk of hand-foot skin reaction with the multitargeted kinase inhibitor sunitinib in patients with renal cell and non-renal cell carcinoma: a meta-analysis.
作者： David Chu , Mario E. Lacouture , Elizabeth Weiner , Shenhong Wu
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摘要: Abstract Hand-foot skin reaction (HFSR) is an emerging issue in cancer treatment with multitargeted tyrosine kinase inhibitors (TKIs), leading to morbidity, suboptimal dosing, and poor compliance. The overall risk of HFSR not clear for sunitinib, a TKI effective metastatic renal cell carcinoma (RCC) gastrointestinal stromal tumor. We therefore conducted systematic review meta-analysis determine the developing sunitinib. Databases from PubMed Web Science articles July 1966 until 2007 abstracts presented at American Society Clinical Oncology conferences were searched identify relevant studies. Eligible studies prospective clinical trials that had described events patients who received singleagent Incidence relative (RR) calculated using random-effects or fixed-effects model. A total 5005 RCC other cancers 10 included analysis. Among receiving summary incidences all-grade high-grade 18.9% (95% CI, 14.1%–24.8%) 5.5% 3.9%–7.9%), respectively. Interestingly, have significantly decreased compared non-RCC malignancy (RR, 0.56; 95% 0.50–0.64; P
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