Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alpha.
作者： Bostjan Kobe
DOI: 10.1038/7625
关键词:
摘要: Importin α is the nuclear import receptor that recognizes classical monopartite and bipartite nuclear localization signals (NLSs). The structure of mouse importin α has been determined …
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nature.com参考文章(54)
K. R. Weiss, B. E. Kemp, B. Kobe, J. Heierhorst, S. C. Feil, M. W. Parker, G. M. Benian, Giant protein kinases: domain interactions and structural basis of autoregulation. The EMBO Journal. ,vol. 15, pp. 6810- 6821 ,(1996) , 10.1002/J.1460-2075.1996.TB01072.X
K. Weis, U. Ryder, A. I. Lamond, The conserved amino-terminal domain of hSRP1 alpha is essential for nuclear protein import. The EMBO Journal. ,vol. 15, pp. 1818- 1825 ,(1996) , 10.1002/J.1460-2075.1996.TB00531.X
Crystallographic and modeling methods in molecular design Springer New York. ,(1990) , 10.1007/978-1-4612-3374-9
Zbyszek Otwinowski, Wladek Minor, Processing of X-ray diffraction data collected in oscillation mode Methods in Enzymology. ,vol. 276, pp. 307- 326 ,(1997) , 10.1016/S0076-6879(97)76066-X
R Ruediger, M Hentz, J Fait, M Mumby, G Walter, Molecular model of the A subunit of protein phosphatase 2A: interaction with other subunits and tumor antigens. Journal of Virology. ,vol. 68, pp. 123- 129 ,(1994) , 10.1128/JVI.68.1.123-129.1994
D. Görlich, P. Henklein, R. A. Laskey, E. Hartmann, A 41 amino acid motif in importin-alpha confers binding to importin-beta and hence transit into the nucleus. The EMBO Journal. ,vol. 15, pp. 1810- 1817 ,(1996) , 10.1002/J.1460-2075.1996.TB00530.X
Bostjan Kobe, Ian G. Jennings, Colin M. House, Belinda J. Michell, Kenneth E. Goodwill, Bernard D. Santarsiero, Raymond C. Stevens, Richard G. H. Cotton, Bruce E. Kemp, Structural basis of autoregulation of phenylalanine hydroxylase Nature Structural & Molecular Biology. ,vol. 6, pp. 442- 448 ,(1999) , 10.1038/8247
D. A. Jans, S. Hubner, Regulation of protein transport to the nucleus: Central role of phosphorylation Physiological Reviews. ,vol. 76, pp. 651- 685 ,(1996) , 10.1152/PHYSREV.1996.76.3.651
Charles R. Kissinger, Hans E. Parge, Daniel R. Knighton, Cristina T. Lewis, Laura A. Pelletier, Anna Tempczyk, Vincent J. Kalish, Kathleen D. Tucker, Richard E. Showalter, Ellen W. Moomaw, Louis N. Gastinel, Noriyuki Habuka, Xinghai Chen, Fausto Maldonado, John E. Barker, Russell Bacquet, J. Ernest Villafranca, Crystal structures of human calcineurin and the human FKBP12–FK506–calcineurin complex Nature. ,vol. 378, pp. 641- 644 ,(1995) , 10.1038/378641A0
Robert M. Esnouf, An extensively modified version of MolScript that includes greatly enhanced coloring capabilities Journal of Molecular Graphics & Modelling. ,vol. 15, pp. 132- 134 ,(1997) , 10.1016/S1093-3263(97)00021-1