Phototherapy in the management of atopic dermatitis: a systematic review

摘要: Background/purpose: Atopic dermatitis (AD) is a common and extremely burdensome skin disorder with limited therapeutic options. Ultraviolet (UV) phototherapy well tolerated, efficacious treatment for AD, but its use by lack of guidelines in the optimal choice modality dosing. Given this deficit, we aim to develop suggestions AD systematically reviewing current medical literature. Methods: Data sources: All data sources were identified through searches MEDLINE via Ovid interface, Cochrane Central Register Controlled Trials, complementary manual literature search. Study selection: Studies selected review met these inclusion criteria, as applied multiple reviewers: controlled clinical trials UV management human subjects reported English-language literature. hand studies which allowed unmonitored topical corticosteroids or immunomodulators excluded. Data extraction: Included assessed independent observers who extracted compiled following data: number patients, duration treatment, cumulative doses radiation, adverse effects, study results. quality was comparing sets rechecking source materials if discrepancy occurred. Results: Nine that criteria identified. Three demonstrated UVA1 both faster more than combined UVAB treating acute AD. Two disclosed advantages medium dose (50 J/cm2) revealed superiority chronic additional narrow-band UVB effective either broad-band UVA managing AD. Conclusion: On basis available evidence, can be made: medium-dose UVA1, available, should used control flares while modalities, specifically UVB,