Infection with Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae in cancer patients

摘要: Klebsiella pneumoniae carbapenemase (KPC)-producing K. (KPC-Kp) is an emergent pathogen in healthcare-associated infections (HAIs). The aim of this study was to describe HAIs due KPC-Kp, as well identify mortality risk factors cancer patients. In patients diagnosed with KPC-Kp between January 2009 and July 2013, we evaluated only the first infection episode each patient, analyzing separately for treated ≥48 h at least one antimicrobial agent proven display vitro activity against KPC-Kp. We variables related malignancy, severity characteristics HAI, therapy. identified 83 30-day 57.8 % all 72.7 bacteremic infections. Of patients, 60 received appropriate treatment 44 (53 %) developed bacteremia. Ten (12 were neutropenic HAI diagnosis 33 (39.8 had tumor site. most common urinary tract infection, seen 26 (31.3 %), followed by primary bloodstream 24 (28.9 %). Forty-four (73.3 combination therapy, often including polymyxin (68.3 Risk are high sequential organ failure assessment (SOFA) score, need intensive care stay acute kidney injury; removal invasive devices effective antibiotics protective factors. associated more than underlying disease.