In situ generated D-peptidic nanofibrils as multifaceted apoptotic inducers to target cancer cells.

摘要: Nanofibrils of small molecules, as a new class biofunctional entities, exhibit emergent properties for controlling cell fates, but the relevant mechanism remains to be elucidated and in vivo effect has yet examined. Here, we show that D-peptide nanofibrils, generated by enzyme-instructed self-assembly (EISA), pleiotropically activate extrinsic death signaling selectively killing cancer cells. Catalyzed alkaline phosphatases formed situ on cells, nanofibrils present autocrine proapoptotic ligands their cognate receptors juxtacrine manner, well directly cluster receptors. As multifaceted initiators, induce apoptosis cells without harming normal co-culture, kill multidrug-resistant (MDR) boost activities anticancer drugs, inhibit tumor growth murine model. Such supramolecular cellular biochemical process (consisting reaction, assembly, binding) multi-targeting or modulating protein-protein interaction networks ultimately may lead ways combating drug resistance.