Functional dedifferentiation of associative resting state networks in older adults - A longitudinal study.

摘要: Healthy aging is associated with weaker functional connectivity within resting state brain networks and stronger interaction between these networks. This phenomenon has been characterized as reduced segregation investigated mainly in cross-sectional studies. Here, we used a longitudinal dataset which consisted of four occasions fMRI psychometric cognitive ability data, collected from sample healthy older adults (baseline N = 232, age range: 64-87 y, M = 70.8 y), to investigate the several well-defined encompassing whole brain. We ratio within-network between-network correlations via well-established index. Our findings showed decrease over 4-year interval default mode, frontoparietal control salience ventral attention In contrast, an increase limbic network same interval. More importantly, rate change was processing speed. These support hypothesis dedifferentiation well its role function elderly.