The Association between TGF-β1 G915C (Arg25Pro) Polymorphism and the Development of Primary Open Angle Glaucoma: A Case-Control Study.

摘要: The purpose of the current study was to identify potential association between Single Nucleotide Polymorphism (SNP) TGFβ1 +915 (C or G) in codon 25 and Primary Open Angle Glaucoma (POAG). Overall, 88 cases with POAG a control group 52 healthy individuals were recruited from First Ophthalmology Department Athens University. DNA isolated whole blood samples genotype frequencies for polymorphism rs1800471 (G915C, Arg25Pro) TGF-β1 gene assessed. Genotype distribution not statistically different patients subjects. present failed determine any significant genotypic POAG, despite fact that presence C allele scarcely increased when compared group.