Synthesis and in vitro photocytotoxicity of coumarin derivatives for one- and two-photon excited photodynamic therapy.
作者： Qianli Zou , Yanyan Fang , Yuxia Zhao , Hongyou Zhao , Ying Wang
DOI: 10.1021/JM400025G
关键词:
摘要: Triethylene glycol functionalized coumarin derivatives 1-5 were synthesized and investigated as photosensitizers for one- two-photon excited photodynamic therapy (PDT). Their absorption, fluorescence, triplet-state quantum yields, singlet oxygen yields found to be significantly related the substituent at 7-position of ring. In vitro photocytotoxicity these toward HepG2 cells was examined compared with a clinical drug. generation reactive species (ROS), cellular uptake, intracellular distribution also characterized fully reveal their structure-property relationships. The results showed that derivative 5, absorption cross section value 1556 GM, could powerful PDT agent both superficial diseases solid tumors.
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