Posttranslational Histone Modifications and the Neurobiology of Psychosis

摘要: Schizophrenia and related major psychiatric disease is typically defined by the conspicuous absence of a defining neuropathology lack straightforward identifiable genetic factors in majority affected individuals. On other hand, there increasing evidence that distinct set RNAs, many which encode proteins critical importance for myelin regulation oligodendrocyte function, or GABAergic inhibitory glutamatergic excitatory neurotransmission are expressed at altered levels diseased brain. This chapter explores mechanisms epigenetic regulators gene expression, including covalent histone modifications, could contribute to dysregulation expression schizophrenia. There also discussion on methodological scientific limitations histone-focused approaches, as it pertains human (postmortem) brain, well brief remarks topic heritability chromatin structures potentially The authors predict study both candidate loci genome-wide, will become an important tool investigation abnormalities potential brains subjects psychosis spectrum.