Neuromodulation and the orchestration of the respiratory rhythm.
作者： Atsushi Doi , Jan-Marino Ramirez
DOI: 10.1016/J.RESP.2008.06.007
关键词:
摘要: The respiratory system is continuously modulated by numerous aminergic and peptidergic substances that act at all levels of integration: from the sensory level to central networks motor nuclei. same neuronal receive inputs multiple modulators released locally as well distal All parameters control are controlled neuromodulators. By partly converging onto similar G-proteins second messenger systems, acetylcholine, norepinephrine, histamine, serotonin (5-HT), dopamine, ATP, substance P, cholecystokinin (CCK) can increase frequency, regularity amplitude activity. Yet, modulator also exert differential effects on activity acting different receptors in neurons. In pre-Botzinger complex (pre-BotC) differentially modulate frequency types pacemaker Similarly motoneurons located nuclei modulation modulators. Thus, capable orchestrating modulating targeting cellular targets. A disturbance modulatory may lead Sudden Infant Death Syndrome (SIDS) erratic breathing.
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