Enteric neural crest-derived cells promote their migration by modifying their microenvironment through tenascin-C production
作者： Sophia E. Akbareian , Nandor Nagy , Casey E. Steiger , John D. Mably , Sarah A. Miller
DOI: 10.1016/J.YDBIO.2013.08.006
关键词:
摘要: Abstract The enteric nervous system (ENS) is derived from vagal and sacral neural crest cells that migrate, proliferate, differentiate into neurons glia within the gut wall. mechanisms regulating crest-derived cell (ENCC) migration are poorly characterized despite importance of this process in formation function. Characterization genes involved ENCC essential to understand ENS development could provide targets for treatment human disorders. We identified extracellular matrix glycoprotein tenascin-C (TNC) as an important regulator development. find TNC dynamically expressed during avian It absent cecal region just prior arrival, but becomes strongly around ENCCs they enter ceca hindgut. In aganglionic hindguts, expression strong throughout outer mesenchyme, submucosal region, supporting presence both ENCC-dependent independent Using rat–chick coelomic grafts, tube cultures, explants, we show produce ECM protein promotes their migration. Interestingly, only express TNC, whereas do not. These results demonstrate actively modify microenvironment through thereby help regulate own
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