Long-term outcome of autoimmune pancreatitis after oral prednisolone therapy.

摘要: Objective: We investigated the long-term outcome of autoimmune pancreatitis (AIP) including morphological changes in pancreas, pancreatic duct, biliary tract, function, and clinical manifestations after oral prednisolone (PSL) therapy. Patients Methods: prospectively followed 12 patients for a period over months (median follow-up period: 41 months; range: from 13 to 133 months). All twelve were treated with PSL. The findings consisted enlargement (n=12), an irregularly narrowed main duct bile stricture (n=10), salivary gland swelling was observed six patients. initial dose PSL 30-40 mg/day, it subsequently tapered. Results: responded pancreas improved almost normal. Pancreatic atrophy developed four them (4/12, 33%), but no calcification any various degrees all 10 , persisted lower part (4/10, 40%). also There recurrence or therapy, recurred one case, three cases there relapse that required temporary increase during tapering. No deterioration exocrine function detected A malignant tumor diagnosed two therapy: early gastric cancer rectal other. are alive. Conclusions: AIP has favorable based on assessments function. However, since malignancy strict follow up should be management AIP.