Seizure predictors and control after microsurgical resection of supratentorial arteriovenous malformations in 440 patients.

摘要: Background Seizures are a common symptom of supratentorial arteriovenous malformations (AVMs), and uncontrolled epilepsy can considerably reduce patient quality life. Potential risk factors for in patients with AVMs poorly understood, the importance achieving freedom from seizures their surgical treatment remains underappreciated. Objective To characterize risks preoperative associated postoperative surgically resected AVMs. Methods We analyzed prospectively collected data 440 who underwent microsurgical resection at our institution. Results Among AVMs, 130 (30%) experienced seizures, 23 (18%) progressed to medically refractory epilepsy. were history AVM hemorrhage (relative risk, 6.65; 95% confidence interval [CI], 3.81-11.6), male sex 2.07; CI, 1.26-3.39), frontotemporal lesion location 1.75; 1.05-2.93). After resection, 96% had modified Engel class I outcome, characterized by (80%) or only 1 seizure (16%; mean follow-up, 20.7 ± 2.3 months). Comparable rates seen (7%) without (3%) seizures. deep artery perforators significantly (hazard ratio, 4.35; 1.61-11.7). Conclusion In hemorrhage, sex, higher whereas Achieving is an important goal that be achieved because diminish