Raynaud's phenomenon in primary Sjögren's syndrome. Prevalence and clinical characteristics in a series of 320 patients.

摘要: OBJECTIVE: To determine the prevalence of Raynaud's phenomenon (RP) in a large series patients with primary Sjogren's syndrome (SS) and to identify clinical immunological features related its presence. METHODS: In cross sectional study, we investigated 320 consecutive SS (294 women, 26 men; mean age at onset 60 yrs, range 16-87 yrs). All fulfilled 4 or more diagnostic criteria for proposed by European Community Study Group 1993. Diagnosis RP was defined as intermittent attacks digital pallor and/or cyanosis absence any other associated disease anatomical abnormalities. RESULTS: present 40 (13%) patients. were 57 yrs (range 18-78). preceded sicca symptomatology 18 (45%) The main triggering factor exposure cold, which induced all patients, while emotional stress 12 job predisposition 2. Fifteen (38%) required pharmacological treatment calcium channel blockers (12 patients) angiotensin converting enzyme inhibitors (2 during colder months, one patient intravenous prostacyclin ischemic complications. Compared without RP, those showed higher articular involvement (50 vs 31%; p = 0.031), cutaneous vasculitis (30 11%; 0.003), antinuclear antibodies (95 65%; < 0.001), anti-Ro/SSA (59 0.001) anti-La/SSB (44 20%, 0.003). CONCLUSION: We found 13% SS, almost half whom first autoimmune symptomatology. These constituted subset frequency some extraglandular positive markers. course seems be milder than systemic diseases such sclerosis, no vascular complications needed only 40%