Role of extracellular signal‑regulated kinase 1/2 signal transduction pathway in insulin secretion by β‑TC6 cells
作者： BEN NIU , LIJUAN LIU , HENG SU , XUESHAN XIA , QIU HE
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摘要: The present study aimed to investigate the role of extracellular signal-regulated kinase (ERK)1/2 signal transduction pathway in glucose‑stimulated insulin secretion β‑TC6 mouse pancreatic cells. Insulin production by cells was stimulated with various concentrations glucose, which dose-dependently inhibited mitogen‑activated protein inhibitor PD98059, as indicated a radioimmunoassay. Furthermore, glucose stimulation enhanced phosphorylation ERK1/2, western blot analysis. These results that activation ERK1/2 may have an important
sci-hub.se 参考文章(20)
Kolandaswamy Anbazhagan, Amrathlal Rabbind Singh, Piec Isabelle, Ibata Stella, Alleaume‐De Martel Céline, Eliane Bissac, Brassart Bertrand, Nyga Rémy, Taylor Naomi, Fuentes Vincent, Jacques Rochette, Kaïss Lassoued, Human pre-B cell receptor signal transduction: evidence for distinct roles of PI3kinase and MAP-kinase signalling pathways Immunity, inflammation and disease. ,vol. 1, pp. 26- 36 ,(2013) , 10.1002/IID3.4
S. R. Shaikh, K. M. Haas, M. A. Beck, H. Teague, The effects of diet-induced obesity on B cell function Clinical and Experimental Immunology. ,vol. 179, pp. 90- 99 ,(2015) , 10.1111/CEI.12444
M. Lawrence, C. Shao, L. Duan, K. McGlynn, M. H. Cobb, The protein kinases ERK1/2 and their roles in pancreatic beta cells. Acta Physiologica. ,vol. 192, pp. 11- 17 ,(2007) , 10.1111/J.1748-1716.2007.01785.X
Premranjan Kumar, G. Nageswar Rao, Bibhuti Bhusan Pal, Arttatrana Pal, Hyperglycemia-induced oxidative stress induces apoptosis by inhibiting PI3-kinase/Akt and ERK1/2 MAPK mediated signaling pathway causing downregulation of 8-oxoG-DNA glycosylase levels in glial cells The International Journal of Biochemistry & Cell Biology. ,vol. 53, pp. 302- 319 ,(2014) , 10.1016/J.BIOCEL.2014.05.038
Zhimin Lu, Shuichan Xu, ERK1/2 MAP kinases in cell survival and apoptosis Iubmb Life. ,vol. 58, pp. 621- 631 ,(2006) , 10.1080/15216540600957438
Gregory Vlacich, Martijn C. Nawijn, Gene C. Webb, Donald F. Steiner, Pim3 negatively regulates glucose-stimulated insulin secretion Islets. ,vol. 2, pp. 308- 317 ,(2010) , 10.4161/ISL.2.5.13058
Christine Longuet, Christophe Broca, Safia Costes, El Habib Hani, Dominique Bataille, Stéphane Dalle, Extracellularly Regulated Kinases 1/2 (p44/42 Mitogen-Activated Protein Kinases) Phosphorylate Synapsin I and Regulate Insulin Secretion in the MIN6 β-Cell Line and Islets of Langerhans Endocrinology. ,vol. 146, pp. 643- 654 ,(2005) , 10.1210/EN.2004-0841
Eri Mukai, Kentaro Toyoda, Hiroyuki Kimura, Hidekazu Kawashima, Hiroyuki Fujimoto, Masashi Ueda, Takashi Temma, Konomu Hirao, Kenji Nagakawa, Hideo Saji, Nobuya Inagaki, GLP-1 receptor antagonist as a potential probe for pancreatic {beta}-cell imaging Biochemical and Biophysical Research Communications. ,vol. 389, pp. 523- 526 ,(2009) , 10.1016/J.BBRC.2009.09.014
Leszek Szablewski, Role of immune system in type 1 diabetes mellitus pathogenesis. International Immunopharmacology. ,vol. 22, pp. 182- 191 ,(2014) , 10.1016/J.INTIMP.2014.06.033
D. Mokhtari, A. Al-Amin, K. Turpaev, T. Li, O. Idevall-Hagren, J. Li, A. Wuttke, R. G. Fred, P. Ravassard, R. Scharfmann, A. Tengholm, N. Welsh, Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol 5′-phosphatase interaction with c-Abl Diabetologia. ,vol. 56, pp. 1327- 1338 ,(2013) , 10.1007/S00125-013-2868-2