Upregulation of rat liver PPARα-FGF21 signaling by a docosahexaenoic acid and thyroid hormone combined protocol.

作者: Luis A. Videla , Virginia Fernández , Romina Vargas , Pamela Cornejo , Gladys Tapia

DOI: 10.1002/BIOF.1300

关键词:

摘要: Prevention of ischemia-reperfusion liver injury is achieved by a combined omega-3 and thyroid hormone (T3 ) protocol, which may involve peroxisome-proliferator activated receptor-α (PPAR-α)-fibroblast growth factor 21 (FGF21) signaling supporting energy requirements. Combined docosahexaenoic acid (DHA; daily doses 300 mg/kg for 3 days) plus 0.05 mg T3 /kg given to fed rats elicited higher hepatic DHA contents serum levels, increased PPAR-α mRNA its DNA binding, with expression the target genes carnitine-palmitoyl transferase 1α, acyl-CoA oxidase, 3-hydroxyl-3-methylglutaryl-CoA synthase 2, effects that were mimicked 0.1 alone or agonist WY-14632. Under these conditions, retinoic X (RXR-α) also increased, concomitant elevation protein FGF21 levels those FGF21. It concluded PPAR-α-FGF21 induction ligand activation enhanced , consequent upregulation controlled PPAR-α. Considering beneficial on carbohydrate lipid metabolism, further investigations are required clarify potential therapeutic applications in human metabolic disorders. © 2016 BioFactors, 42(6):638-646, 2016.

参考文章(50)
Bozo, Cornejo P, Videla La, Vargas R, Andrade M, Ortega Y, Fernandez, Minuzzi G, Thyroid hormone activates rat liver adenosine 5,-monophosphate-activated protein kinase: relation to CaMKKb, TAK1 and LKB1 expression and energy status. Journal of Biological Regulators and Homeostatic Agents. ,vol. 27, pp. 989- ,(2013)
Xiong Deng, Qingming Dong, Dave Bridges, Rajendra Raghow, Edwards A. Park, Marshall B. Elam, Docosahexaenoic acid inhibits proteolytic processing of sterol regulatory element-binding protein-1c (SREBP-1c) via activation of AMP-activated kinase. Biochimica et Biophysica Acta. ,vol. 1851, pp. 1521- 1529 ,(2015) , 10.1016/J.BBALIP.2015.08.007
S. Zhu, L. Ma, Y. Wu, X. Ye, T. Zhang, Q. Zhang, L. M. Rasoul, Y. Liu, M. Guo, B. Zhou, G. Ren, D. Li, FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathway Acta Biochimica et Biophysica Sinica. ,vol. 46, pp. 1041- 1048 ,(2014) , 10.1093/ABBS/GMU097
Cristiana E. Juge-Aubry, Agnieszka Gorla-Bajszczak, Agns Pernin, Thomas Lemberger, Walter Wahli, Albert G. Burger, Christoph A. Meier, Peroxisome Proliferator-activated Receptor Mediates Cross-talk with Thyroid Hormone Receptor by Competition for Retinoid X Receptor POSSIBLE ROLE OF A LEUCINE ZIPPER-LIKE HEPTAD REPEAT Journal of Biological Chemistry. ,vol. 270, pp. 18117- 18122 ,(1995) , 10.1074/JBC.270.30.18117
B Desvergne, B Staels, J Auwerx, T Lemberger, W Wahli, R Saladin, Regulation of the peroxisome proliferator-activated receptor alpha gene by glucocorticoids Journal of Biological Chemistry. ,vol. 269, pp. 24527- 24530 ,(1994) , 10.1016/S0021-9258(17)31420-5
Pamela Cornejo, Romina Vargas, Luis A. Videla, Nrf2-regulated phase-II detoxification enzymes and phase-III transporters are induced by thyroid hormone in rat liver Biofactors. ,vol. 39, pp. 514- 521 ,(2013) , 10.1002/BIOF.1094
Luis A. Videla, Virginia Fernández, Pamela Cornejo, Romina Vargas, Juan Carrasco, Javier Fernández, Nelson Varela, Causal role of oxidative stress in unfolded protein response development in the hyperthyroid state Free Radical Biology and Medicine. ,vol. 89, pp. 401- 408 ,(2015) , 10.1016/J.FREERADBIOMED.2015.09.004
Rashmi Mullur, Yan-Yun Liu, Gregory A. Brent, Thyroid Hormone Regulation of Metabolism Physiological Reviews. ,vol. 94, pp. 355- 382 ,(2014) , 10.1152/PHYSREV.00030.2013
Virginia Fernández, Iván Castillo, Gladys Tapia, Pamela Romanque, Sebastián Uribe-Echevarría, Mario Uribe, Denise Cartier-Ugarte, Gonzalo Santander, María T. Vial, Luis A. Videla, Thyroid hormone preconditioning: protection against ischemia-reperfusion liver injury in the rat. Hepatology. ,vol. 45, pp. 170- 177 ,(2007) , 10.1002/HEP.21476