作者: Luis A. Videla , Virginia Fernández , Romina Vargas , Pamela Cornejo , Gladys Tapia
DOI: 10.1002/BIOF.1300
关键词:
摘要: Prevention of ischemia-reperfusion liver injury is achieved by a combined omega-3 and thyroid hormone (T3 ) protocol, which may involve peroxisome-proliferator activated receptor-α (PPAR-α)-fibroblast growth factor 21 (FGF21) signaling supporting energy requirements. Combined docosahexaenoic acid (DHA; daily doses 300 mg/kg for 3 days) plus 0.05 mg T3 /kg given to fed rats elicited higher hepatic DHA contents serum levels, increased PPAR-α mRNA its DNA binding, with expression the target genes carnitine-palmitoyl transferase 1α, acyl-CoA oxidase, 3-hydroxyl-3-methylglutaryl-CoA synthase 2, effects that were mimicked 0.1 alone or agonist WY-14632. Under these conditions, retinoic X (RXR-α) also increased, concomitant elevation protein FGF21 levels those FGF21. It concluded PPAR-α-FGF21 induction ligand activation enhanced , consequent upregulation controlled PPAR-α. Considering beneficial on carbohydrate lipid metabolism, further investigations are required clarify potential therapeutic applications in human metabolic disorders. © 2016 BioFactors, 42(6):638-646, 2016.