Competing endogenous RNA networks: tying the essential knots for cancer biology and therapeutics

摘要: A recently discovered dimension of post-transcriptional gene regulation involves co-regulatory crosstalk between RNA transcripts, which compete for common pools microRNA (miRNA) molecules. These competing endogenous RNAs (ceRNAs), or natural miRNA sponges, have an active role in regulating availability within the cell and form intertwined regulatory networks. Recent reports implicated diverse species including protein-coding messenger non-coding as ceRNAs human development diseases cancer. In this review, we discuss most recent discoveries that implicate decoys cancer biology, well exciting advances study ceRNA networks dynamics. The structure topology intricate genome-scale can be predicted computationally, their dynamic response to fluctuations levels studied via mathematical modeling. Additionally, new methods quantitatively determine absolute expression molecules expanded capacity accurately efficiency biological models. major milestones are critical importance identify key components could aid approaches diagnostics oligonucleotide-based therapeutics.