Sodium acetate ameliorated systemic and renal oxidative stress in high-fructose insulin-resistant pregnant Wistar rats.

摘要: Pregnancy is an insulin-resistant condition especially at near term predisposing maternal kidneys to hyperinsulinemia-induced oxidative stress. The impact of fructose on renal metabolic dysregulation and stress in pregnancy requires elucidation. Short-chain fatty acids (SCFAs) are known for protective roles conditions. Therefore, the study aimed investigating fructose-induced glucose pregnant non-pregnant rats possible preventive role SCFA, acetate. Thirty female Wistar were grouped (n = 5/group). Three groups made (P); other three remained (NP). Both received drinking water (control), 10% (w/v) (NP+F or P+F), plus sodium acetate (200 mg/kg) (NP+F+A P+F+A) 3 weeks. Renal plasma glutathione antioxidant index (GSH/GSSG), G6PDH, adenosine significantly lower NP+F P+F compared with control while deaminase (ADA), xanthine oxidase (XO), uric acid (UA), lactate dehydrogenase (LDH), malonaldehyde (MDA) elevated controls. HOMA-IR showed marked impairment both groups. group revealed greater suppression G6PDH-dependent index, adenosine, aggravation LDH, MDA (p < 0.05). Sodium reduces surrogate markers, improved G6PD-dependent exacerbates insulin resistance whereas ameliorated redox rats.