Are anti-ribosomal P protein antibodies relevant in systemic lupus erythematosus?

摘要: Systemic lupus erythematosus (SLE) is a prototypal auto-immune disorder characterized with multiple organ involvement resulting in disability and increased mortality. Immune regulatory disturbances cumulate activation of B cells consequent auto-antibody production. Antigens for these auto-antibodies can be nuclear components cytoplasmic elements. Anti-P antibodies react against acidic phosphorylated ribosomal proteins P0, P1, P2 (with molecular mass 38, 19, 17 kDa, respectively) are located on the S60 subunit ribosomes. Ribosomal P share common 22-amino acid sequence that present carboxyl-terminal. detected approx 15 to 20% patients by several immunoassays, most frequently enzyme-linked immunosorbent assay (ELISA) and/or Western blotting. However, no standardized available. Auto-antibodies eukaryotic appear highly specific SLE; therefore, they used as diagnostic marker disease. Furthermore, association has been described particular manifestations lupus, especially neuropsychiatric, renal, hepatic involvements. positivity titer anti-P also fluctuate clinical disease activity. Despite lines evidence, results conflicting regarding existence such associations. Discrepancies explained different study set-up or population; it attributed sensitivity tests detection antibody.