Noise in Neurons and Other Constraints

摘要: How do the properties of signalling molecules constrain structure and function biological networks such as those our brain? Here we focus on action potential, fundamental electrical signal brain, because malfunction potential causes many neurological conditions. The is mediated by concerted voltagegated ion channels relating these to neurons at systems level essential for biomedical brain research, minor variations in a individual component, can have large, pathological effects physiology whole nervous system behaviour it generates. This approach very complex requires us discuss computational methods that span across levels organization, from single proteins organization entire system, encompassing time scales milliseconds hours.Within this methodical framework, will how relate functional structural requirements axonal engineering design principles their axons (nerve fibres). important, not only are wires allow information transmission between neurons, but also they play crucial neural computation itself.