Effect of crust and seed hydro-alcoholic and aqueous extracts and pulp hydro-alcoholic extract of Citrullus colocynthis on glucose, insulin and FIRI level in insulin resistant male rat’s
作者： A A Oroojan , A Ahangarpour
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摘要: Aims: The most common use of Citrullus colocynthis is to treat diabetes and decrease blood glucose in Iranian traditional medicine. Due the effects fructose on increasing creating insulin resistant (IR) models, this study aimed compare effect different parts extract male rats. Methods: In experimental study, 63 adult Wistar rats were used. After making IR with 10% induced drinking water for 8 weeks, animals divided into 7 (control, sham, aqueous hydro-alcoholic extracts crust seed pulp) groups. separation serums, glucose, resistance index measured. results statistically analyzed by ANOVA post hoc LSD tests. Results: Hydro-alcoholic increased comparison control group (p<0.05). Glucose level was decreased sham Weight (p<0.01) (p<0.05) leads decreasing seed’s group, compared (p<0.01). Insulin (p<0.001) Conclusion: effective part treatment type II harmful crust.
参考文章(33)
F Fallahhossini, A Nourouzzadeh, R Sharifabady, H Ghoshouni, A B Zareei Mahmoudabadi, H Imani, The Effect of Citrullus Colocynthis Extract on Preventing/ Reducing Streptozotocin- Induced Diabetes in Rat Trauma monthly. ,vol. 12, pp. 13- 20 ,(2007)
Jeyanthi K.A, Antioxidant Effect Of Citrullus Colocynthis On Alloxan Induced Diabetic Rats International Journal of Pharmaceutical & Biological Archive. ,vol. 2, ,(2011)
Soter Dai, John H. McNeill, Fructose-induced hypertension in rats is concentration- and duration-dependent. Journal of Pharmacological and Toxicological Methods. ,vol. 33, pp. 101- 107 ,(1995) , 10.1016/1056-8719(94)00063-A
Stephanie Seneff, Glyn Wainwright, Luca Mascitelli, Is the metabolic syndrome caused by a high fructose, and relatively low fat, low cholesterol diet? Archives of Medical Science. ,vol. 7, pp. 8- 20 ,(2011) , 10.5114/AOMS.2011.20598
Walid Sh. Qazan ., Motasem M. Almasad ., Haytham Daradka ., Short and long effects of Citrullus colocynthis L. on reproductive system and fertility in female Spague-Dawley rats. Pakistan Journal of Biological Sciences. ,vol. 10, pp. 2699- 2703 ,(2007) , 10.3923/PJBS.2007.2699.2703
Issa Abed Abdel-Hassan, Jamal Ahmed Abdel-Barry, Sarah Tariq Mohammeda, The hypoglycaemic and antihyperglycaemic effect of citrullus colocynthis fruit aqueous extract in normal and alloxan diabetic rabbits. Journal of Ethnopharmacology. ,vol. 71, pp. 325- 330 ,(2000) , 10.1016/S0378-8741(99)00215-9
Erdem Yesilada, Shigeo Tanaka, Ekrem Sezik, Mamoru Tabata, Isolation of an anti-inflammatory principle from the fruit juice of Ecballium elaterium. Journal of Natural Products. ,vol. 51, pp. 504- 508 ,(1988) , 10.1021/NP50057A008
Anwar Borai, Callum Livingstone, Ibrahim Kaddam, Gordon Ferns, Selection of the appropriate method for the assessment of insulin resistance BMC Medical Research Methodology. ,vol. 11, pp. 158- 158 ,(2011) , 10.1186/1471-2288-11-158
Xiu-ping BI, Hong-wei TAN, Shan-shan XING, Zhi-hao WANG, Meng-xiong TANG, Yun ZHANG, Wei ZHANG, Overexpression of TRB3 Gene in Adipose Tissue of Rats with High Fructose-induced Metabolic Syndrome Endocrine Journal. ,vol. 55, pp. 747- 752 ,(2008) , 10.1507/ENDOCRJ.K08E-049
Po-Shiuan Hsieh, Yueh-Hua Tai, Ching-Hui Loh, Kuang-Chung Shih, Wei-Tung Cheng, Chi-Hong Chu, Functional interaction of AT1 and AT2 receptors in fructose-induced insulin resistance and hypertension in rats. Metabolism-clinical and Experimental. ,vol. 54, pp. 157- 164 ,(2005) , 10.1016/J.METABOL.2004.07.016