Melatonin for non-operating room sedation in paediatric population: a systematic review and meta-analysis.

摘要: Context The literature on melatonin as a sedative agent in children is limited. Objective To conduct systematic review of studies assessing the efficacy and safety for non-operating room sedation children. Methods Medline, Embase, Cochrane Library Cumulative Index to Nursing Allied Health were searched until 9 April 2020 using reporting one prespecified outcomes this review. Two authors independently assessed eligibility, risk bias extracted data. Studies with similar study design, comparator procedure pooled fixed-effect model. Results 25 (clinical trials=3, observational studies=9, descriptive studies=13) included. Melatonin was used electroencephalogram (EEG) (n=12), brainstem evoked response audiometry (n=8) magnetic resonance imaging (MRI) (n=5). No significant differences noted meta-analysis EEG comparing sleep deprivation (SD) (relative (RR) 1.06 (95% CI 0.99 1.12)), chloral hydrate (RR 0.97 0.89 1.05)) alone SD combined 1.03 1.10)) successful completion. However, significantly higher failure compared 1.55 1.02 2.33)) EEG. Additionally, showed lower latency (mean difference −10.21 −11.53 −8.89) major adverse events reported melatonin. Conclusion Although several identified, no serious concerns noted, evidence not high quality establish melatonin’s