Therapeutic implications of the choroid plexus-cerebrospinal fluid interface in neuropsychiatric disorders.

摘要: The choroid plexus (CP) comprises an epithelial monolayer that forms important physical, enzymatic and immunologic barrier, called the blood-cerebrospinal fluid barrier (BCSFB). It is a highly vascularized organ located in brain ventricles key maintaining homeostasis as it produces cerebrospinal (CSF) has other secretory functions. Furthermore, CP-CSF interface plays putative role neurogenesis been implicated neuropsychiatric diseases such neurodevelopmental disorders schizophrenia autism. A for this CNS border was also sleep disturbances chronic and/or severe stress, which are risk factors development of conditions. Understanding mechanisms by disturbance at involved these different low-grade inflammatory can give new insights into therapeutic strategies. Hence, review discusses roles have suggested so far CP disorders, with special attention to potential applications.