Wrapping Drug Combinations for Therapeutic Editing of Side Effects: Systems Biology Meets Wrapping Technology

摘要: Wrapping designs have limitations arising from similarities in the biomolecular interfaces of on-target and off-target homologous proteins also highly diverse cellular contexts wherein a protein may constitute desirable or undesirable target. While dehydron wrapping enables control specificity, it not be able to exclude every single toxicity-related target, especially if latter shares with therapeutically relevant targets similar pattern drug-binding region. In such circumstances, we need resort multicomponent therapy where one drug acts synergistically other while selectively antagonizing specific context action first promotes toxicity. This chapter explores these a-priori therapeutic possibilities. As previously described, due their ability interfere signal transduction events controlling cell proliferation fate, kinase inhibitors hold promise as anticancer agents. Nevertheless, functional role depends on hence inhibition an lead undesired side effects. Motivated by observations, explore mode “therapeutic editing” drug—the editor—suppresses effect promoted primary impacts cells. Editor overlapping impact, editor suppresses downstream propagation signaling triggered context.