AEG-1/MTDH/LYRIC: A Promiscuous Protein Partner Critical in Cancer, Obesity, and CNS Diseases.
作者： L. Emdad , S.K. Das , B. Hu , T. Kegelman , D.-c. Kang
DOI: 10.1016/BS.ACR.2016.05.002
关键词:
摘要: Since its original discovery in 2002, AEG-1/MTDH/LYRIC has emerged as a primary regulator of several diseases including cancer, inflammatory diseases, and neurodegenerative diseases. key contributory molecule almost every aspect cancer progression, uncontrolled cell growth, evasion apoptosis, increased migration invasion, angiogenesis, chemoresistance, metastasis. Additionally, recent studies highlight seminal role obesity. By interacting with multiple protein partners, plays multifaceted roles the pathogenesis wide variety This review discusses current state understanding regulation function other focus on association/interaction pivotal partners.
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