Modelling the cost-effectiveness of public awareness campaigns for the early detection of non-small-cell lung cancer.

摘要: Survival rates in lung cancer England are significantly lower than many similar countries. A range of Be Clear on Cancer (BCOC) campaigns have been conducted targeting and found to improve the proportion diagnoses at early stage disease. This paper considers cost-effectiveness such campaigns, evaluating effect both regional national BCOC distribution non-small-cell (NSCLC) diagnosis. natural history model NSCLC was developed using incidence data, data elicited from clinical experts calibration techniques. structure is used consider lifetime cost quality-adjusted survival implications awareness campaigns. Incremental ratios (ICERs) terms additional costs per life-years (QALYs) gained presented. Two scenario analyses were investigate role changes ‘worried-well’ population route diagnosis that might occur as a result The base-case theoretical be associated with QALY gains 289 178 QALYs ICERs £13 660 £18 173 gained, respectively. scenarios increases may impact conclusions. Subject available evidence, analysis suggests potential cost-effective. However, significant research required address limitations this study. In addition, estimated presents previously unavailable estimates prevalence rate disease progression undiagnosed population.