Efficacy of Zinc Against Common Cold Viruses: An Overview

摘要: Objective: To review the laboratory and clinical evidence of medicinal value zinc for treatment common cold. Data Sources: Published articles identified through Medline (1980‐2003) using search terms zinc, rhinovirus, other pertinent subject headings. Additional sources were from bibliographies retrieved articles. Study Selection: By author. Extraction: Synthesis: Human rhinoviruses, by attaching to nasal epithelium via intracellular adhesion molecule-1 (ICAM-1) receptor, cause most colds. Ionic based on its electrical charge, also has an affinity ICAM-1 receptor sites may exert antiviral effect receptors in rhinovirus structure epithelial cells. Clinical tests colds have been inconsistent, primarily because study design, blinding, lozenge contents. Early formulations lozenges unpalatable. In three trials with similar designs, methodologies, efficacy assessments, effectively significantly shortened duration cold when it was administered within 24 hours onset symptoms. Recent reports gluconate as a gel supported these findings; addition, they shown that is effective reducing severity symptoms patients established illness. Conclusion: trial data support evaluations are warranted further define role ionic prevention elucidate biochemical