The Alkalizer Citrate Reduces Serum Uric Acid Levels and Improves Renal Function in Hyperuricemic Patients Treated with the Xanthine Oxidase Inhibitor Allopurinol

摘要: Objective. Hyperuricemia, an integral component of metabolic syndrome, is a major health problem causing gout and renal damage. Urine alkalizers such as citrate preparations facilitate excretion the uric acid, but its supportive effect on xanthine oxidase inhibitors has not been tested yet. We performed randomized, prospective study combination allopurinol preparation function in patients with hyperuricemia, employing 70 who had hyperuricemia serum acid levels ≥7.0 mg/dL, or those diagnosed having past. Methods. They were randomly enrolled into two groups: monotherapy (MT) group treatment (CT) preparation. Allopurinol (100–200 mg/day) absence presence (3 g/day) was administered for 12 weeks urinary clearance (Cua), glomerular filtration rates assessed w...