Dietary fat and immune function. I. Antibody responses, lymphocyte and accessory cell function in (NZB x NZW)F1 mice.

摘要: The influence of dietary fat on autoimmunity in lupus-prone (NZB x NZW)F1 mice has been demonstrated. In defining further the effects lipid immune system this strain, female weanling were placed four diets differing quantity and type fat. Their immunologic response was then studied by a variety tests at 4 7 mo age. Few differences seen among groups At age, however, receiving high saturated unsaturated fats had reduced mitogenic to T cell mitogens an enhanced B mitogen LPS. Immunoglobulin levels delayed hypersensitivity responses did not show any consistent diet groups. mo, demonstrated hyperresponsiveness injected sheep red blood cells as measured hemolytic plaque technique. addition, peritoneal leukocytes from same group exhibited increased bromelain-treated autologous erythrocytes which decreased after treatment with anti-Thy-1 antiserum complement. Phagocytosis macrophages significantly animals fed high-fat diets, particular Similarly, natural killer activity markedly intake lipid, finding correlated vitro production interferon. These results indicate that thus can affect onset severity autoimmune disease. A low-fat reduce development disease maintaining normal responses. data also suggest may helper therefore antibody production, whereas cellular are dependent membrane contact.