Annexin/S100A Protein Family Regulation through p14ARF-p53 Activation: A Role in Cell Survival and Predicting Treatment Outcomes in Breast Cancer
作者： Diana Hatoum , Daniel Yagoub , Alireza Ahadi , Najah T. Nassif , Eileen M. McGowan
DOI: 10.1371/JOURNAL.PONE.0169925
关键词:
摘要: The annexin family and S100A associated proteins are important regulators of diverse calcium-dependent cellular processes including cell division, growth regulation apoptosis. Dysfunction individual is with cancer progression, metastasis drug resistance. This manuscript describes the novel finding differential by activation p53 in breast cells. Additionally, observed found to be beneficial survival cells influence treatment efficacy. We have used unbiased, quantitative proteomics determine proteomic changes occurring post p14ARF-p53 estrogen receptor (ER) In this report we identified annexin/S100A family, through unique peptide recognition at N-terminal regions, demonstrating a central orchestrator calcium favor pro-survival functions cell. was cell-type specific. Retrospective human studies demonstrated that tumors functional wild type (p53wt) respond poorly some chemotherapy agents compared non-functional p53. Given modulation signaling has been change sensitivity chemotherapeutic apoptotic signals, principle, explored paradigm how ER+ patients impacts influences therapeutic outcomes.
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Sei-Hyun Ahn, Hidetomo Sawada, Jae-Y Ro, Garth L. Nicolson, Differential expression of annexin I in human mammary ductal epithelial cells in normal and benign and malignant breast tissues Clinical & Experimental Metastasis. ,vol. 15, pp. 151- 156 ,(1997) , 10.1023/A:1018452810915
Anjana Bhardwaj, Nivetha Ganesan, Kazunoshin Tachibana, Kimal Rajapakshe, Constance T. Albarracin, Preethi H. Gunaratne, Cristian Coarfa, Isabelle Bedrosian, Annexin A1 Preferentially Predicts Poor Prognosis of Basal-Like Breast Cancer Patients by Activating mTOR-S6 Signaling. PLOS ONE. ,vol. 10, ,(2015) , 10.1371/JOURNAL.PONE.0127678
Carlotta Giorgi, Massimo Bonora, Paolo Pinton, Inside the tumor: p53 modulates calcium homeostasis. Cell Cycle. ,vol. 14, pp. 933- 934 ,(2015) , 10.1080/15384101.2015.1010973
Marcelo Sobral-Leite, Jelle Wesseling, Vincent THBM Smit, Heli Nevanlinna, Martine H van Miltenburg, Joyce Sanders, Ingrid Hofland, Fiona M Blows, Penny Coulson, Gazinska Patrycja, Jan HM Schellens, Rainer Fagerholm, Päivi Heikkilä, Kristiina Aittomäki, Carl Blomqvist, Elena Provenzano, Hamid Raza Ali, Jonine Figueroa, Mark Sherman, Jolanta Lissowska, Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M Hartikainen, Kelly-Anne Phillips, kConFab/AOCS Investigators, Fergus J Couch, Janet E Olson, Celine Vachon, Daniel Visscher, Hermann Brenner, Katja Butterbach, Volker Arndt, Bernd Holleczek, Maartje J Hooning, Antoinette Hollestelle, John WM Martens, Carolien HM van Deurzen, Bob van de Water, Annegien Broeks, Jenny Chang-Claude, Georgia Chenevix-Trench, Douglas F Easton, Paul DP Pharoah, Montserrat García-Closas, Marjo de Graauw, Marjanka K Schmidt, Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis BMC Medicine. ,vol. 13, pp. 156- 156 ,(2015) , 10.1186/S12916-015-0392-6
Jyoti K Jaiswal, Jesper Nylandsted, S100 and annexin proteins identify cell membrane damage as the Achilles heel of metastatic cancer cells. Cell Cycle. ,vol. 14, pp. 502- 509 ,(2015) , 10.1080/15384101.2014.995495
S Takahashi, S V Reddy, J M Chirgwin, R Devlin, C Haipek, J Anderson, G D Roodman, Cloning and identification of annexin II as an autocrine/paracrine factor that increases osteoclast formation and bone resorption. Journal of Biological Chemistry. ,vol. 269, pp. 28696- 28701 ,(1994) , 10.1016/S0021-9258(19)61961-7
Anna Alvarez-Guaita, Sandra Vilà de Muga, Dylan M Owen, David Williamson, Astrid Magenau, Ana García-Melero, Meritxell Reverter, Monira Hoque, Rose Cairns, Rhea Cornely, Francesc Tebar, Thomas Grewal, Katharina Gaus, Jesús Ayala-Sanmartín, Carlos Enrich, Carles Rentero, Evidence for annexin A6-dependent plasma membrane remodelling of lipid domains. British Journal of Pharmacology. ,vol. 172, pp. 1677- 1690 ,(2015) , 10.1111/BPH.13022
Yidong Liu, Helene K Myrvang, Lodewijk V Dekker, Annexin A2 complexes with S100 proteins: structure, function and pharmacological manipulation British Journal of Pharmacology. ,vol. 172, pp. 1664- 1676 ,(2015) , 10.1111/BPH.12978
Evrim Gurpinar, Karen H. Vousden, Hitting cancers’ weak spots: vulnerabilities imposed by p53 mutation Trends in Cell Biology. ,vol. 25, pp. 486- 495 ,(2015) , 10.1016/J.TCB.2015.04.001
Tong Wang, Jie Yuan, Jie Zhang, Ran Tian, Wei Ji, Yan Zhou, Yi Yang, Weijie Song, Fei Zhang, Ruifang Niu, Anxa2 binds to STAT3 and promotes epithelial to mesenchymal transition in breast cancer cells Oncotarget. ,vol. 6, pp. 30975- 30992 ,(2015) , 10.18632/ONCOTARGET.5199