Chronic lymphocytic leukaemia cells drive the global CD4+ T cell repertoire towards a regulatory phenotype and leads to the accumulation of CD4+ forkhead box P3+ T cells.

摘要: Advanced chronic lymphocytic leukaemia (CLL) is associated with profound immunodeficiency, including changes in T regulatory cells (T(regs)). We determined the pattern of expression forkhead box P3 (FoxP3), CD25, CD27 and CD127 showed that frequency CD4+ FoxP3+ was increased CLL patients (12% versus 8% controls). This increase seen only advanced disease, selective expansion FoxP3-expressing CD25(low) population, whereas number CD25(high) unchanged. reduced CD27, this phenotype also on all CD4 subsets patients, irrespective CD25 or FoxP3 expression. Incubation primary tumours led to a sixfold CD25- cells. Patients undergoing treatment fludarabine demonstrated transient percentage cells, but normal levels post-treatment. work demonstrates exhibit systemic cell dysregulation leading accumulation appears be driven by interaction malignant understanding mechanisms are involved could provide novel avenues for treatment.