Cristaxenicin A, an Antiprotozoal Xenicane Diterpenoid from the Deep Sea Gorgonian Acanthoprimnoa cristata
作者： Shin-Taro Ishigami , Yasuyuki Goto , Noboru Inoue , Shin-Ichiro Kawazu , Yoshitsugu Matsumoto
DOI: 10.1021/JO302109G
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摘要: A new xenicane diterpenoid, cristaxenicin (1), has been isolated from the deep sea gorgonian Acanthoprimnoa cristata. The structure of 1 was elucidated on basis spectral analysis including NMR and MS. absolute configuration determined quantum chemical calculation CD spectra. Cristaxenicin (1) showed antiprotozoal activities against Leishmania amazonensis Trypanosoma congolense with IC50 values 0.088 0.25 μM, respectively.
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