Transcriptional regulatory cascades controlling plasma cell differentiation.
作者： Kuo-I Lin , Chainarong Tunyaplin , Kathryn Calame
DOI: 10.1034/J.1600-065X.2003.00040.X
关键词:
摘要: Summary: Plasma cells are the terminally differentiated effector of B lymphocyte lineage. Recently, studies using genetically altered mice and analyses global gene expression programs have significantly expanded our understanding molecular mechanisms regulating plasmacytic differentiation. Specific components a multistep cascade transcriptional regulators been identified. Furthermore, two regulators, X box binding protein-1 (XBP-1) induced maturation (Blimp-1), shown to be necessary for In addition providing mechanistic basis induction genes immunoglobulin secretion, cessation cell cycle other phenotypic changes characteristic plasma cells, these led important concept that differentiation involves repression such as Bcl-6 Pax5, maintain earlier developmental phenotype activated, germinal center cells. This review describes current cascades terminal
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