The humoral response in the pathogenesis of gluten ataxia
作者： M. Hadjivassiliou , S. Boscolo , G. A.B. Davies–Jones , R. A. Grünewald , T. Not
关键词:
摘要: Objective: To characterize humoral response to cerebellum in patients with gluten ataxia. Background: Gluten ataxia is a common neurologic manifestation of sensitivity. Methods: The authors assessed the reactivity sera from (13), newly diagnosed celiac disease without dysfunction (24), other causes cerebellar degeneration (11), and healthy control subjects (17) using indirect immunocytochemistry on human rat CNS tissue. Cross-reactivity commercial IgG antigliadin antibody tissue also was studied. Results: Sera 12 13 stained Purkinje cells strongly. Less intense staining seen some but not all dysfunction. At high dilutions (1:800) only subjects. brainstem cortical neurons Commercial anti-gliadin similar manner. Adsorption antibodies crude gliadin abolished dysfunction, those Conclusions: Patients have against cells. Antigliadin cross-react epitopes
elsevier.com
units.it参考文章(15)
Angelo Ghezzi, Massimo Filippi, Andrea Falini, Mauro Zaffaroni, Cerebral involvement in celiac disease: A serial MRI study in a patient with brainstem and cerebellar symptoms Neurology. ,vol. 49, pp. 1447- 1450 ,(1997) , 10.1212/WNL.49.5.1447
Kurt A. Jaeckle, Francesc Graus, Alan Houghton, Carlos Cardon-Cardo, Surl L Nielsen, Jerome B. Posner, Autoimmune response of patients with paraneoplastic cerebellar degeneration to a Purkinje cell cytoplasmic protein antigen. Annals of Neurology. ,vol. 18, pp. 592- 600 ,(1985) , 10.1002/ANA.410180513
M Hadjivassiliou, RA Grünewald, AK Chattopadhyay, GAB Davies-Jones, A Gibson, JA Jarratt, RH Kandler, A Lobo, T Powell, CML Smith, Clinical, radiological, neurophysiological, and neuropathological characteristics of gluten ataxia The Lancet. ,vol. 352, pp. 1582- 1585 ,(1998) , 10.1016/S0140-6736(98)05342-2
Franz Blaes, David Beeson, Paul Plested, Bethan Lang, Angela Vincent, IgG from "seronegative" myasthenia gravis patients binds to a muscle cell line, TE671, but not to human acetylcholine receptor. Annals of Neurology. ,vol. 47, pp. 504- 510 ,(2000) , 10.1002/1531-8249(200004)47:4<504::AID-ANA14>3.0.CO;2-Q
P. Collin, T. Pirttila, T. Nurmikko, H. Somer, T. Erila, O. Keyrilainen, Celiac disease, brain atrophy, and dementia Neurology. ,vol. 41, pp. 372- 372 ,(1991) , 10.1212/WNL.41.3.372
K. P. Bhatia, P. Brown, R. Gregory, G. G. Lennox, H. Manji, P. D. Thompson, D. W. Ellison, C. D. Marsden, Progressive myoclonic ataxia associated with coeliac disease. The myoclonus is of cortical origin, but the pathology is in the cerebellum. Brain. ,vol. 118, pp. 1087- 1093 ,(1995) , 10.1093/BRAIN/118.5.1087
Tarcisio Not, Roberto Marzari, A Bradbury, C Trevisiol, I Berti, A Fasano, A Tommasini, Daniele Sblattero, Alessandro Ventura, Human recombinant tissue transglutaminase ELISA: an innovative diagnostic assay for celiac disease The American Journal of Gastroenterology. ,vol. 95, pp. 1253- 1257 ,(2000) , 10.1016/S0002-9270(00)00810-8
W. T. COOKE, W. THOMAS SMITH, NEUROLOGICAL DISORDERS ASSOCIATED WITH ADULT CELIAC DISEASE Brain. ,vol. 89, pp. 683- 722 ,(1966) , 10.1093/BRAIN/89.4.683
M Hadjivassiliou, A Gibson, G.A.B Davies-Jones, A.J Lobo, T.J Stephenson, A Milford-Ward, Does cryptic gluten sensitivity play a part in neurological illness? The Lancet. ,vol. 347, pp. 369- 371 ,(1996) , 10.1016/S0140-6736(96)90540-1
M. T. Pellecchia, R. Scala, A. Filla, G. De Michele, C. Ciacci, P. Barone, Idiopathic cerebellar ataxia associated with celiac disease: lack of distinctive neurological features Journal of Neurology, Neurosurgery, and Psychiatry. ,vol. 66, pp. 32- 35 ,(1999) , 10.1136/JNNP.66.1.32