The adenovirus-inducible factor E2F stimulates transcription after specific DNA binding.
作者： A S Yee , P Raychaudhuri , L Jakoi , J R Nevins
DOI: 10.1128/MCB.9.2.578
关键词:
摘要: The promoter-specific factor E2F interacts with critical regulatory sequences within the adenovirus E2 promoter. In addition, level of active increases markedly during a virus infection, dependent on E1A function and coincident trans activation transcription. We have purified through combination standard biochemical procedures DNA affinity chromatography. was single polypeptide 54,000 molecular weight, as determined by UV crosslinking renaturation gel-fractionated protein. Addition affinity-purified to an in vitro transcription system resulted stimulation from promoter containing two E2F-binding sites but not promoters lacking binding sites. thus conclude that is indeed capable stimulating once it has bound
sci-hub.se 参考文章(42)
S. Yoshinaga, N. Dean, M. Han, A.J. Berk, Adenovirus stimulation of transcription by RNA polymerase III: evidence for an E1A-dependent increase in transcription factor IIIC concentration The EMBO Journal. ,vol. 5, pp. 343- 354 ,(1986) , 10.1002/J.1460-2075.1986.TB04218.X
P. Raychaudhuri, R. Rooney, J. R. Nevins, Identification of an E1A-inducible cellular factor that interacts with regulatory sequences within the adenovirus E4 promoter. The EMBO Journal. ,vol. 6, pp. 4073- 4081 ,(1987) , 10.1002/J.1460-2075.1987.TB02753.X
Joseph R. Nevins, [70] Definition and mapping of adenovirus 2 nuclear transcription Nucleic Acids Part I. ,vol. 65, pp. 768- 785 ,(1980) , 10.1016/S0076-6879(80)65072-1
G Haegeman, W Fiers, Characterization of the 5'-terminal cap structures of early simian virus 40 mRNA. Journal of Virology. ,vol. 35, pp. 955- 961 ,(1980) , 10.1128/JVI.35.3.955-961.1980
D.K. Hawley, R.G. Roeder, Functional Steps in Transcription Initiation and Reinitiation from the Major Late Promoter in a HeLa Nuclear Extract Journal of Biological Chemistry. ,vol. 262, pp. 3452- 3461 ,(1987) , 10.1016/S0021-9258(18)61372-9
V B Reddy, P K Ghosh, P Lebowitz, M Piatak, S M Weissman, Simian virus 40 early mRNA's. I. Genomic localization of 3' and 5' termini and two major splices in mRNA from transformed and lytically infected cells. Journal of Virology. ,vol. 30, pp. 279- 296 ,(1979) , 10.1128/JVI.30.1.279-296.1979
M J Imperiale, H T Kao, L T Feldman, J R Nevins, S Strickland, Common control of the heat shock gene and early adenovirus genes: evidence for a cellular E1A-like activity. Molecular and Cellular Biology. ,vol. 4, pp. 867- 874 ,(1984) , 10.1128/MCB.4.5.867
S P Eisenberg, D M Coen, S L McKnight, Promoter domains required for expression of plasmid-borne copies of the herpes simplex virus thymidine kinase gene in virus-infected mouse fibroblasts and microinjected frog oocytes. Molecular and Cellular Biology. ,vol. 5, pp. 1940- 1947 ,(1985) , 10.1128/MCB.5.8.1940
N C Jones, J D Richter, D L Weeks, L D Smith, Regulation of adenovirus transcription by an E1a gene in microinjected Xenopus laevis oocytes. Molecular and Cellular Biology. ,vol. 3, pp. 2131- 2142 ,(1983) , 10.1128/MCB.3.12.2131
L A Chodosh, R W Carthew, P A Sharp, A single polypeptide possesses the binding and transcription activities of the adenovirus major late transcription factor. Molecular and Cellular Biology. ,vol. 6, pp. 4723- 4733 ,(1986) , 10.1128/MCB.6.12.4723