Conjugates of vip and active fragments thereof with hydrophobic moieties and topical compositions for male impotence

作者: Illana Gozes , Matityahu Fridkin

DOI:

关键词:

摘要: There are provided pharmaceutical compositions for topical transdermal application the treatment of male impotence. The active ingredients such selected from vasoactive intestinal peptide (VIP), effective derivatives thereof and fragments thereof. In impotence a transdermally conjugate VIP, its or coupled to hydrophogic moiety, is used.

参考文章(13)
Minoru Kobota, Karl Folkers, Anders Ljungquist, Cyril Y. Bowers, Pui-Fun Louisa Tang, Dong-Mei Feng, Effective antagonists of the luteinizing hormone releasing hormone which release negligible histamine ,(1988)
David R. Bolin, Iou-Iou Sytwu, Johannes A. Meienhofer, Synthetic vasoactive intestinal peptide analogs ,(1986)
Lorin K. Johnson, John A. Lewicki, Robert M. Scarborough, Cyclic analogs of atrial natriuretic peptides ,(1989)
David H. Coy, William A. Murphy, Mark L. Heiman, Therapeutic Somatostatin analogues ,(1988)
Michael J. Baum, Roberta B. Todd, Paul C. Doherty, Effects of Chronic Hyperprolactinemia on Sexual Arousal and Erectile Function in Male Rats Neuroendocrinology. ,vol. 42, pp. 368- 375 ,(1986) , 10.1159/000124474
C. B. Pert, J. M. Hill, M. R. Ruff, R. M. Berman, W. G. Robey, L. O. Arthur, F. W. Ruscetti, W. L. Farrar, Octapeptides deduced from the neuropeptide receptor-like pattern of antigen T4 in brain potently inhibit human immunodeficiency virus receptor binding and T-cell infectivity. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 83, pp. 9254- 9258 ,(1986) , 10.1073/PNAS.83.23.9254
JAN FAHRENKRUG, BENT OTTESEN, CONNIE PALLE, Vasoactive intestinal polypeptide and the reproductive system. Annals of the New York Academy of Sciences. ,vol. 527, pp. 393- 404 ,(1988) , 10.1111/J.1749-6632.1988.TB26995.X