A pilot study of streptokinase‐induced endothelial injury and platelet activation following acute myocardial infarction

摘要: Abstract. Lip GYH, Lydakis C, Nuttall SL, Landray MJ, Watson RDS, Blann AD (Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK). A pilot study streptokinase-induced endothelial injury platelet activation following acute myocardial infarction. J Intern Med248: 316–318. Objective. To relate the changes in serum vitamin E, an essential antioxidant, to fibrinogen, as well indices damage [as indicated by plasma markers, soluble thrombomodulin (sTM) von Willebrand factor (vWf)], index [soluble P selectin (sPsel)], infarction treated with thrombolytic therapy. Design Setting. Prospective longitudinal a teaching hospital Coronary Care Unit. Subjects intervention. Seventeen patients (12 men; mean age 62 years ± SD 11 years) admitted (AMI), who were given therapy, 59 healthy controls. Results. Baseline levels fibrinogen (Mann–Whitney test, P = 0.0055) vWf (P < 0.001) significantly higher than controls, but sPsel, sTM or E not different. Following thrombolysis, expected, median concentrations fell profoundly (Friedman anovaP < 0.001) so that after 45 min, undetectable 13 patients. At 24-h concentration had recovered approximately 30% baseline (P < 0.01) was still three Levels sPsel increased steadily, reaching significance hours (both P < 0.05). However, rose immediately peaking between 1 3 h, remained elevated at 24 h. These increases corresponded simultaneous early fall concentrations. Conclusion. The present demonstrates significant association oxidative stress streptokinase therapy for AMI.