Protein and lipid metabolism in nephrotic infants on peritoneal dialysis after nephrectomy

摘要: Congenital nephrotic syndrome of the Finnish type (CNF) is associated with protein deficiency despite substantial supplementation in state before nephrectomy. Different intakes (2.5 vs. 3.7 g/kg per day) hypoproteinaemic children on continuous cycling peritoneal dialysis (CCPD) were studied. Lipids also measured to determine whether severe atherogenic abnormalities seen during nephrosis improved after Growth was normal or became both intakes. Serum pre-albumin and transferrin concentrations normal. Total (57±3.0 reference limits 60–75 g/l) albumin (28±5.0 30–50 but remained below normal, even higher intake. Muscle mass determined by measuring femoral quadriceps muscle thickness using ultrasound markedly reduced all patients at It (P<0.05) 2 who had several bacterial infections, reached level only 3 within 6 months. Plasma total, very low-density lipoprotein (VLDL) (LDL) triglyceride decreased (P<0.05,P<0.05 andP<0.01, respectively) VLDL, LDL high-density (HDL) particles contained less than state. HDL cholesterol increased 28% [0.58±0.22 mmol/l nephrosis, 0.81±0.21 CCPD nephrectomy (P<0.05)] 1.38±0.75 controls (P<0.001). If compared there still significant CCPD. Hence, a intake 2.5 day representing 140% recommended dietary allowance sufficient maintain growth improve nutritional status CNF Although lipid levels they abnormal.