Human and Nonhuman Primate Lineage-Specific Footprints in the Salivary Proteome.

摘要: Proteins in saliva are needed for preprocessing food the mouth, maintenance of tooth mineralization, and protection from microbial pathogens. Novel insights into human lineage-specific functions salivary proteins clues to their involvement disease can be gained through evolutionary studies, as recently shown amylase AMY1 agglutinin DMBT1/gp340. However, entirety saliva, proteome, has not yet been investigated an perspective. Here, we compared proteomes our closest extant relatives, chimpanzees gorillas, using macaques outgroup, with aim uncover features protein composition that unique each species. We found humans produce a waterier containing less than half total great apes Old World monkeys. For all major humans, could identify counterparts chimpanzee gorilla saliva. discovered profiles were distinct those nonhuman primates. These findings open up possibility dietary differences pathogenic pressures may have shaped proteome lineage.