Spleen tyrosine kinase: an Src family of non-receptor kinase has multiple functions and represents a valuable therapeutic target in the treatment of autoimmune and inflammatory diseases.
作者： Debjani Ghosh , George C. Tsokos
DOI: 10.3109/08916930903374717
关键词:
摘要: Spleen tyrosine kinase (Syk) is involved in the development and function of B T cells, Fc receptor-mediated degranulation basophils mast cells. Recent work has assigned important roles for Syk aberrant cells patients with systemic lupus erythematosus (SLE), osteoclasts, urate crystal-induced neutrophil stimulation. Preclinical early clinical studies have urged inhibition treatment rheumatoid arthritis, whereas ex vivo experiments preclinical point to a therapeutic potential SLE arthritides.
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